Sugi Predict

Sugi Predict / Compounds / SCHEMBL646937

SCHEMBL646937

SCHEMBL646937

[c]1[nH]c(-c2cc3ccccc3[nH]2)c2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 4/20 0.47
▸ NPC1 O15118 3/20 0.47
▸ ITK Q08881 5/20 0.46
▸ KDM4E B2RXH2 4/20 0.42
▸ MAPT P10636 4/20 0.42
▸ MEN1 O00255 3/20 0.42
▸ ALDH1A1 P00352 3/20 0.42
▸ HPGD P15428 3/20 0.42
▸ KMT2A Q03164 3/20 0.42
▸ CASP3 P42574 2/20 0.42
▸ SENP8 Q96LD8 2/20 0.42
▸ SENP7 Q9BQF6 2/20 0.42
▸ SENP6 Q9GZR1 2/20 0.42
▸ CHEK1 O14757 1/20 0.42
▸ KDR P35968 1/20 0.42
▸ CYP1A2 P05177 1/20 0.42
▸ CYP2C9 P11712 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42
▸ TUBB4A P04350 1/20 0.41
▸ TUBB P07437 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1257288 0.75 RAB9A (0.52) RAB9ANPC1ITKKDM4EMAPT
SCHEMBL2045033 0.73 RAB9A (0.53) RAB9ANPC1ITKKDM4EMAPT
SCHEMBL31555117 0.73 RAB9A (0.53) RAB9ANPC1ITKKDM4EMAPT
SCHEMBL374022 0.72 RAB9A (0.74) RAB9ANPC1ITKKDM4EMAPT
SCHEMBL29631691 0.72 RAB9A (0.74) RAB9ANPC1ITKKDM4EMAPT
SCHEMBL14829610 0.71 RAB9A (0.52) RAB9ANPC1ITKKDM4EMAPT
SCHEMBL11363931 0.71 KDR (0.63) RAB9ANPC1ITKKDM4EMAPT
SCHEMBL5264609 0.70 RAB9A (0.46) RAB9ANPC1ITKKDM4EMAPT
SCHEMBL10176240 0.70 KDR (0.61) RAB9ANPC1ITKKDM4EMAPT
SCHEMBL6336392 0.69 RAB9A (0.53) RAB9ANPC1ITKKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110197876-B Electronic device and lighting device 三星显示有限公司 2024-07-02 — — CN disclosed
CN-117813306-A Heterocyclic compounds as KRAS inhibitors, their preparation and therapeutic use 上海科州药物研发有限公司 2024-04-02 — — CN disclosed
CN-117203205-A Triazolone, tetrazolone and imidazolone or salts thereof, and pharmaceutical compositions containing the same 柳韩洋行 2023-12-08 — — CN disclosed
CN-111740024-B organic light emitting device 三星显示有限公司 2023-08-25 — — CN disclosed
CN-115715804-A Use of carotenoids in the treatment of age-related disorders 阿尔加克蒂夫有限公司 2023-02-28 — — CN disclosed
US-10202400-B2 Cortistatin analogues and syntheses thereof PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2019-02-12 — — US disclosed
US-20170320886-A1 CORTISTATIN ANALOGUES AND SYNTHESES THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2017-11-09 — — US disclosed
US-9714255-B2 Cortistatin analogues and syntheses thereof PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2017-07-25 — — US disclosed
EP-3062790-A1 PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF CANCER Pitney Pharmaceuticals Pty Limited (AU) 2016-09-07 — — EP disclosed
US-20150376201-A1 CORTISTATIN ANALOGUES AND SYNTHESES THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2015-12-31 — — US disclosed
EP-1581517-A1 SUBSTITUTED 1-PIPERIDIN-4-YL-4-AZETIDIN-3-YL-PIPERAZINE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2005-10-05 — — EP disclosed
WO-2005082079-A2 TETRACYCLIC LACTAM DERIVATIVES AND USES THEREOF INOTEK PHARMACEUTICALS CORPORATION (US) 2005-09-09 — — WO disclosed
WO-2005009398-A2 TETRACYCLIC BENZAMIDE DERIVATIVES AND METHODS OF USE THEREOF INOTEK PHARMACEUTICALS CORPORATION (US) 2005-02-03 — — WO disclosed
US-20040229895-A1 Tetracyclic benzamide derivatives and methods of use thereof INOTEK PHARMACEUTICALS CORPORATION 2004-11-18 — — US disclosed
US-6809111-B2 ANTIINFLAMMATORY AGENTS; ANALGESICS PHARMACIA CORPORATION 2004-10-26 — — US disclosed
WO-2004056800-A1 SUBSTITUTED 1-PIPERIDIN-4-YL-4-AZETIDIN-3-YL-PIPERAZINE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2004-07-08 — — WO disclosed
US-6730671-B2 ENZYME INHIBITOR TREATING AUTOIMMUNE DISEASES, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2004-05-04 — — US disclosed
US-6395897-B1 DRUGS FOR ENZYME INHIBITORS ANTICOAGULANTS AND TREATMENT OF AUTOIMMUNE DISEASE BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2002-05-28 — — US disclosed
EP-1025137-A1 PHOTO-POLYMERIZATION OF VINYL CHLORIDE USING METALLOCENE CATALYSTS OCCIDENTAL CHEMICAL CORPORATION (US) 2000-08-09 — — EP disclosed
WO-1999023124-A1 PHOTO-POLYMERIZATION OF VINYL CHLORIDE USING METALLOCENE CATALYSTS OCCIDENTAL CHEMICAL CORPORATION (US) 1999-05-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10202400-B2 Cortistatin analogues and syntheses thereof CTTN, TEK, FLT1 RAB9A 968/4885NPC1 2016/4885ITK 1403/4885
US-20150376201-A1 CORTISTATIN ANALOGUES AND SYNTHESES THEREOF CTTN, TEK, FLT1 RAB9A 968/4885NPC1 2016/4885ITK 1403/4885
US-20040229895-A1 Tetracyclic benzamide derivatives and methods of use thereof TBC1D5, TBC1D15, BAD RAB9A 4250/4885NPC1 3780/4885ITK 945/4885
US-20170320886-A1 CORTISTATIN ANALOGUES AND SYNTHESES THEREOF CTTN, TEK, FLT1 RAB9A 968/4885NPC1 2016/4885ITK 1403/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.