SCHEMBL374022

SCHEMBL374022

c1ccc2[nH]c(-c3cc4ccccc4[nH]3)cc2c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.74
NPC1 O15118 3/20 0.74
KDM4E B2RXH2 5/20 0.63
MAPT P10636 5/20 0.63
HPGD P15428 4/20 0.63
MEN1 O00255 3/20 0.63
ALDH1A1 P00352 3/20 0.63
KMT2A Q03164 3/20 0.63
CASP3 P42574 2/20 0.63
SENP8 Q96LD8 2/20 0.63
SENP7 Q9BQF6 2/20 0.63
SENP6 Q9GZR1 2/20 0.63
CHEK1 O14757 1/20 0.63
KDR P35968 1/20 0.63
CYP1A2 P05177 1/20 0.63
CYP2C9 P11712 1/20 0.63
CYP2C19 P33261 1/20 0.63
AOC3 Q16853 2/20 0.58
CYP19A1 P11511 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29631691 1.00 RAB9A (0.74) RAB9ANPC1KDM4EMAPTHPGD
SCHEMBL5051826 0.87 KDR (0.68) RAB9ANPC1KDM4EMAPTHPGD
SCHEMBL5053299 0.87 NPC1 (0.87) RAB9ANPC1KDM4EMAPTHPGD
Phosphoric Acid SCHEMBL7651467 0.87 RAB9A (0.59) RAB9ANPC1KDM4EMAPTHPGD
Methane SCHEMBL28704887 0.85 KDR (0.66) RAB9ANPC1KDM4EMAPTHPGD
2-Phenyl-1H-Indole SCHEMBL29363616 0.85 NPC1 (1.00) RAB9ANPC1KDM4EMAPTHPGD
SCHEMBL28416625 0.85 NPC1 (0.83) RAB9ANPC1KDM4EMAPTHPGD
Benzene SCHEMBL27629233 0.85 RAB9A (0.69) RAB9ANPC1KDM4EMAPTHPGD
2-Phenyl-1H-Indole SCHEMBL341378 0.85 NPC1 (1.00) RAB9ANPC1KDM4EMAPTHPGD
SCHEMBL10226021 0.85 NPC1 (0.68) RAB9ANPC1KDM4EMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108822016-A A kind of synthetic method of biindolyl class material 赵东敏 2018-11-16 CN claimed
US-7038043-B1 Glycosylated indolocarbazole synthesis YALE UNIVERSITY (US) 2006-05-02 US claimed
US-6586357-B1 Stereospecific catalysts; enantioselective reduction; transition metal complexes CHEMI S.P.A. (IT) 2003-07-01 US claimed
EP-0770085-B1 HETEROAROMATIC DIPHOSPHINES AS CHIRAL LIGANDS CHEMI SPA (IT) 1999-09-22 EP claimed
WO-1997007081-A2 GLYCOSYLATED INDOLOCARBAZOLE SYNTHESIS YALE UNIVERSITY (US) 1997-02-27 WO claimed
WO-1996001831-A1 HETEROAROMATIC DIPHOSPHINES AS CHIRAL LIGANDS ITALFARMACO SUD S.P.A. (IT) 1996-01-25 WO claimed
JP-9110831-A None JP disclosed
JP-9249875-A None JP disclosed
CN-118007121-A Method and device for improving separation efficiency of phosphating slag 中国第一汽车股份有限公司 2024-05-10 CN disclosed
EP-3700909-B1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2024-01-24 EP disclosed
US-11807715-B2 Ring-opening polymerizations using a flow reactor INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2023-11-07 US disclosed
US-11807715-B2 Ring-opening polymerizations using a flow reactor INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2023-11-07 US disclosed
CN-108440507-B Compound as apoptosis protein inhibitor and application thereof 南京圣和药物研发有限公司 2022-10-18 CN disclosed
JP-H09110831-A PRODUCTION OF 2,2'-BISINDOLE DERIVATIVE KISSEI PHARMACEUT CO LTD 1997-04-28 JP disclosed
US-5616724-A FOR POTENTIATION OF HUMAN INTERFERON-GAMMA; IMMUNOLOGY CEPHALON, INC. (US) 1997-04-01 US disclosed
WO-1997007081-A2 GLYCOSYLATED INDOLOCARBAZOLE SYNTHESIS YALE UNIVERSITY (US) 1997-02-27 WO disclosed
EP-0725844-A4 1996-09-11 EP disclosed
EP-0725844-A1 A PROCESS FOR ACTIVATING A METAL SURFACE FOR CONVERSION COATING HENKEL CORPORATION (US) 1996-08-14 EP disclosed
WO-1996001831-A1 HETEROAROMATIC DIPHOSPHINES AS CHIRAL LIGANDS ITALFARMACO SUD S.P.A. (IT) 1996-01-25 WO disclosed
WO-1995012011-A1 A PROCESS FOR ACTIVATING A METAL SURFACE FOR CONVERSION COATING HENKEL CORPORATION (US) 1995-05-04 WO disclosed