Pantoprazole

Pantoprazole

SCHEMBL6469440

COc1ccnc(C[S+]([O-])c2nc3cc(OC(F)F)ccc3[nH]2)c1OC.COc1ccnc(C[S+]([O-])c2nc3cc(OC(F)F)ccc3[nH]2)c1OC

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATP4A P20648 14/20 0.54
ATP4B P51164 14/20 0.54
CYP2C9 P11712 2/20 0.54
KDM4E B2RXH2 1/20 0.54
SLC22A2 O15244 1/20 0.54
DDAH1 O94760 1/20 0.54
ALDH1A1 P00352 1/20 0.54
LMNA P02545 1/20 0.54
ABCB1 P08183 1/20 0.54
CYP3A4 P08684 1/20 0.54
MAPT P10636 1/20 0.54
HPGD P15428 1/20 0.54
ALOX15 P16050 1/20 0.54
ADRA1A P35348 1/20 0.54
FASN P49327 1/20 0.54
SLC47A2 Q86VL8 1/20 0.54
SLC47A1 Q96FL8 1/20 0.54
ABCG2 Q9UNQ0 1/20 0.54
ATP1A1 P05023 7/20 0.45
ATP1B1 P05026 7/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pantoprazole SCHEMBL4942069 1.00 ATP4A (0.54) ATP4AATP4BCYP2C9KDM4ESLC22A2
Pantoprazole SCHEMBL4192305 1.00 ATP4A (0.54) ATP4AATP4BCYP2C9KDM4ESLC22A2
Pantoprazole SCHEMBL29465 1.00 ATP4A (0.54) ATP4AATP4BCYP2C9KDM4ESLC22A2
Pantoprazole SCHEMBL29425016 1.00 ATP4A (0.54) ATP4AATP4BCYP2C9KDM4ESLC22A2
Pantoprazole SCHEMBL12662938 1.00 ATP4A (0.54) ATP4AATP4BCYP2C9KDM4ESLC22A2
Pantoprazole SCHEMBL1716777 0.99 ATP4A (0.53) ATP4AATP4BCYP2C9KDM4ESLC22A2
Pantoprazole SCHEMBL6262319 0.99 ATP4A (0.53) ATP4AATP4BCYP2C9KDM4ESLC22A2
Pantoprazole SCHEMBL4320242 0.99 ATP4A (0.53) ATP4AATP4BCYP2C9KDM4ESLC22A2
Pantoprazole SCHEMBL1994484 0.99 ATP4A (0.53) ATP4AATP4BCYP2C9KDM4ESLC22A2
Pantoprazole SCHEMBL3716300 0.99 ATP4A (0.53) ATP4AATP4BCYP2C9KDM4ESLC22A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050165041-A1 Combination for the treatment of airway disorders ALTANA PHARMA AG (DE) 2005-07-28 US claimed
EP-3675838-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS Puretecch LYT, Inc. (US) 2020-07-08 EP disclosed
WO-2019046491-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS ARIYA THERAPEUTICS, INC. (US) 2019-03-07 WO disclosed
CN-101134036-B Preparations containing rebeprazole and sodium bicarbonate and method for preparing the same XINYI MEDICAL FACTORY 2013-05-01 CN disclosed
CN-101134036-A Preparations containing rebeprazole and sodium bicarbonate and method for preparing the same XINYI MEDICAL FACTORY (CN) 2008-03-05 CN disclosed