Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL157129 | 0.88 | KDM4E (0.67) | ALDH1A1KDM4EKMT2AADRA2AADRA2B | |
| Trifluoroacetic Acid SCHEMBL6470237 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4EL3MBTL1ATMADRA2A | |
| SCHEMBL2148186 | 0.79 | ALDH1A1 (0.60) | ALDH1A1KDM4EKMT2AL3MBTL1ATM | |
| Trifluoroacetic Acid SCHEMBL2807127 | 0.76 | FLT3 (0.49) | KMT2AKITFLT3VNN1 | |
| Trifluoroacetic Acid SCHEMBL185821 | 0.76 | FLT3 (0.49) | KMT2AKITFLT3VNN1 | |
| Trifluoroacetic Acid SCHEMBL28707107 | 0.74 | TSHR (0.50) | ALDH1A1KMT2AL3MBTL1ATMTSHR | |
| Trifluoroacetic Acid SCHEMBL30012492 | 0.74 | TSHR (0.50) | ALDH1A1KMT2AL3MBTL1ATMTSHR | |
| SCHEMBL157288 | 0.74 | KDM4E (1.00) | ALDH1A1KDM4EKMT2AL3MBTL1TSHR | |
| Trifluoroacetic Acid SCHEMBL30261497 | 0.72 | L3MBTL1 (0.55) | ALDH1A1KDM4EKMT2AL3MBTL1P4HTM | |
| Trifluoroacetic Acid SCHEMBL1787547 | 0.72 | L3MBTL1 (0.55) | ALDH1A1KDM4EKMT2AL3MBTL1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | ALDH1A1 2820/4885KDM4E 3151/4885KMT2A 2085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.