SCHEMBL6470277

SCHEMBL6470277

COC(=O)CCc1cc(-n2nc3ccccc3n2)c(O)cc1C(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.44
POLB P06746 1/20 0.44
NPC1 O15118 4/20 0.40
RAB9A P51151 4/20 0.40
LMNA P02545 1/20 0.40
GAA P10253 1/20 0.38
RPS6KB2 Q9UBS0 1/20 0.38
ALDH1A1 P00352 4/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
HPGD P15428 3/20 0.37
HSD17B10 Q99714 1/20 0.37
TSHR P16473 1/20 0.37
CCNC P24863 1/20 0.36
CDK8 P49336 1/20 0.36
MAPT P10636 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
PDE10A Q9Y233 1/20 0.35
PPARG P37231 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3297999 0.87 KDM4E (0.44) KDM4EPOLBNPC1RAB9ALMNA
SCHEMBL7068865 0.80 GAA (0.47) KDM4EPOLBNPC1RAB9ALMNA
SCHEMBL14274957 0.80 KDM4E (0.39) KDM4EPOLBLMNAGAARPS6KB2
SCHEMBL21310184 0.80 KDM4E (0.44) KDM4EPOLBNPC1RAB9ALMNA
SCHEMBL29350844 0.80 GAA (0.47) KDM4EPOLBNPC1RAB9ALMNA
SCHEMBL31360 0.80 GAA (0.47) KDM4EPOLBNPC1RAB9ALMNA
SCHEMBL5693424 0.78 LMNA (0.51) KDM4EPOLBNPC1RAB9ALMNA
SCHEMBL14429821 0.77 KDM4E (0.43) KDM4EPOLBNPC1RAB9ALMNA
SCHEMBL14620822 0.77 KMT2A (0.44) KDM4EPOLBNPC1RAB9AGAA
SCHEMBL7593809 0.77 MAOB (0.45) KDM4EPOLBLMNAGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112601668-B Thermosensitive recording material and color-developing agent 索理思科技开曼公司 2022-07-29 CN disclosed
CN-112601668-A Thermosensitive recording material and color-developing agent 索理思科技开曼公司 2021-04-02 CN disclosed
US-20210002215-A1 HEAT SENSITIVE RECORDING MATERIAL AND COLOR DEVELOPER SOLENIS TECHNOLOGIES CAYMAN, L.P. (KY) 2021-01-07 US disclosed
EP-3533619-A1 HEAT SENSITIVE RECORDING MATERIAL AND COLOR DEVELOPER BASF SE (DE) 2019-09-04 EP disclosed
EP-2794558-B1 HEAT SENSITIVE COATING COMPOSITION BASF SE (DE) 2017-04-26 EP disclosed
US-20140342293-A1 HEAT SENSITIVE COATING COMPOSITION BASF SE (DE) 2014-11-20 US disclosed
EP-2794558-A1 HEAT SENSITIVE COATING COMPOSITION BASF SE (DE) 2014-10-29 EP disclosed
WO-2013093755-A1 HEAT SENSITIVE COATING COMPOSITION BASF SE (DE) 2013-06-27 WO disclosed
US-20050221982-A1 Heat sensitive recording material CIBA SPECIALTY CHEMICALS CORP. 2005-10-06 US disclosed
EP-1480835-A1 HEAT SENSITIVE RECORDING MATERIAL Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
WO-2003074285-A1 HEAT SENSITIVE RECORDING MATERIAL CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
WO-2002078970-A1 HEAT SENSITIVE RECORDING MATERIAL CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2002-10-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210002215-A1 HEAT SENSITIVE RECORDING MATERIAL AND COLOR DEVELOPER SCN1A, NCS1, SCN4A KDM4E 1188/4885POLB 3714/4885NPC1 4413/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.