NCS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL17287798	1.00	1/20
SCHEMBL17287822	0.75	1/20
SCHEMBL6766057	0.70	1/20
SCHEMBL13949524	0.67	1/20
SCHEMBL4858014	0.66	1/20
SCHEMBL5313704	0.66	1/20
SCHEMBL6206186	0.66	1/20
SCHEMBL7933388	0.66	1/20
Ethylene (SCHEMBL8167289)	0.66	1/20
SCHEMBL2431114	0.65	1/20
SCHEMBL19612098	0.65	1/20
SCHEMBL17770327	0.64	1/20
SCHEMBL3933070	0.64	1/20
SCHEMBL5070926	0.64	1/20
SCHEMBL1580942	0.64	1/20
SCHEMBL5184333	0.64	1/20
SCHEMBL17287819	0.64	1/20
SCHEMBL11887784	0.64	1/20
SCHEMBL4862601	0.63	1/20
SCHEMBL18289908	0.63	1/20

Clinical trials — most relevant to NCS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Minocycline for the Treatment of Early-Phase Schizophrenia	PHASE3	COMPLETED
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction	PHASE2	ACTIVE_NOT_RECRUITING
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
A Phase I/II, First-In-Human Trial to Evaluate the Safety, Tolerability, and Pharmacokinetic Activity to Prevent or Treat Neuropsychiatric Symptoms in Pediatric Subjects With Timothy Syndrome	PHASE1/PHASE2	NOT_YET_RECRUITING
Vibration Therapy Effects on Muscle Firing Patterns	PHASE1/PHASE2	COMPLETED
EDTA Eye Drops Compared to Abreva for Herpes Simplex Virus Eruptions	PHASE2	COMPLETED
TRPM8 Activators for Peripheral Neuropathy	PHASE2	ACTIVE_NOT_RECRUITING
Population Pharmacokinetic-pharmacodynamic (PK-PD) Modeling of Co-administered Gabapentin in Neuropathic Pain	PHASE2	COMPLETED
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Pain Processing and Pain Neuroscience Education in Children With Chronic Abdominal Pain	nan	COMPLETED
Add-on HD Hf-tRNS Over Bilateral DLPFC for Treating Patients With Schizophrenia	nan	COMPLETED
Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients	nan	RECRUITING
Measuring Single Neuron Activity in the Brain	nan	NOT_YET_RECRUITING
Multicenter Study of Patients With SHANK3 Mutations: Identification of Genes Modificators in Phelan-McDermid Syndrome (EUQ13)	nan	NOT_YET_RECRUITING
The Prevalence of RYR1-related Disease	nan	NOT_YET_RECRUITING
Long Term Transcranial Pulse Stimulation (TPS) on Older Adults With Mild Neurocognitive Disorder (NCD)	nan	UNKNOWN
Protein Synthesis in the Brain of Patients With Fragile X Syndrome	nan	COMPLETED
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins.	nan	UNKNOWN
Urine Concentration of S100B in Extremely Premature Infants	nan	COMPLETED
Relationship of Gestational Age and Urine Concentration of S100B in Preterm and Term Infants in the First Week of Life	nan	COMPLETED
Exploring the Genetics of Neuropathic Pain	nan	RECRUITING
Biomarkers in Chemotherapy-Induced Peripheral Neurotoxicity	nan	COMPLETED
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis	nan	UNKNOWN
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN
BIOmarkers of MIGraine: a Proof of Concept Study Based on the Stratification of Responders to CGRP Monoclonal Antibodies	nan	COMPLETED
Susceptibility Genes in Autism Spectrum Disorders	nan	COMPLETED
SCN1A Horizons A Natural History Study of SCN1A-related Epilepsies in the United Kingdom	nan	RECRUITING
Neurogenic Mechanisms in Burning Mouth Syndrome	nan	COMPLETED
EXploring novEl Molecular Determinants of DRAvet Syndrome Phenotype Heterogeneity	nan	UNKNOWN
Duration of Analgesia in Bier Block for Patients Undergoing Hand Surgery	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a NCS1 binder may also engage these)

Protein	Name	Similarity
Q5RC90	—	1.000	Q5RC90 →
Q2V8Y7	—	1.000	Q2V8Y7 →
P62167	—	1.000	P62167 →
Q8BNY6	—	1.000	Q8BNY6 →
Q91614	—	1.000	Q91614 →
P62762	—	1.000	P62762 →
Q5R6S5	—	1.000	Q5R6S5 →
P36608	—	1.000	P36608 →
P62168	—	1.000	P62168 →
Q4R5F7	—	0.998	Q4R5F7 →
P37236	—	0.998	P37236 →
Q9VWX8	—	0.998	Q9VWX8 →
Q06389	—	0.997	Q06389 →
Q3YLA4	—	0.997	Q3YLA4 →
Q16981	—	0.997	Q16981 →
P29105	—	0.997	P29105 →
Q28IM6	—	0.996	Q28IM6 →
P37235	—	0.996	P37235 →
Q6DCM9	—	0.996	Q6DCM9 →
P62748	—	0.995	P62748 →
P29104	—	0.995	P29104 →
Q09711	—	0.995	Q09711 →
P35332	—	0.994	P35332 →
Q9UM19	—	0.994	Q9UM19 →
P62760	—	0.994	P62760 →
B3VSB7	—	0.994	B3VSB7 →
Q06AT0	—	0.994	Q06AT0 →
B5FZ84	—	0.994	B5FZ84 →
Q7SY75	—	0.994	Q7SY75 →
Q4PL64	—	0.993	Q4PL64 →