Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043113 | 0.84 | HTR1A (0.41) | NOS3NOS2EPHX2CPB2SMN1; SMN2 | |
| SCHEMBL5130593 | 0.83 | CA2 (0.42) | NOS3NOS2EPHX2CPB2SMN1; SMN2 | |
| SCHEMBL5040583 | 0.82 | EPHX2 (0.36) | NOS3NOS2EPHX2CPB2SMN1; SMN2 | |
| SCHEMBL5131540 | 0.81 | KDM4E (0.38) | NOS3NOS2EPHX2CPB2SMN1; SMN2 | |
| SCHEMBL23107162 | 0.81 | FDFT1 (0.36) | SMN1; SMN2MCHR1CYP3A4SLC6A4CHRM2 | |
| SCHEMBL6470688 | 0.79 | KMT2A (0.39) | SMN1; SMN2MCHR1OPRM1RAB9AKMT2A | |
| SCHEMBL3653564 | 0.78 | CYP3A4 (0.43) | SMN1; SMN2CYP3A4SLC6A4CHRM2HTR1A | |
| SCHEMBL5133502 | 0.76 | KDM4E (0.36) | NOS3NOS2EPHX2CPB2CYP3A4 | |
| Hydrochloric Acid SCHEMBL2934770 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP3A4SLC6A4CHRM2HTR1A | |
| SCHEMBL5133792 | 0.75 | SMN1; SMN2 (0.49) | EPHX2SMN1; SMN2CASRADRB2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | claimed |
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | NOS3 1287/4885NOS2 1936/4885EPHX2 2162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.