Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.46 |
| ▸ | PDE4A | P27815 | 9/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472450 | 0.94 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CP2RX7 | |
| SCHEMBL6473039 | 0.87 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CP2RX7 | |
| SCHEMBL6472458 | 0.84 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6470693 | 0.84 | HTT (0.44) | — | |
| SCHEMBL6533416 | 0.81 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6470711 | 0.80 | LMNA (0.40) | — | |
| SCHEMBL6471016 | 0.79 | PDE4B (0.42) | PDE4BPDE4DPDE4APDE4CP2RX7 | |
| SCHEMBL6470724 | 0.79 | PDE4B (0.41) | PDE4BPDE4DPDE4APDE4CP2RX7 | |
| SCHEMBL6472455 | 0.78 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4CP2RX7 | |
| SCHEMBL6471502 | 0.74 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4CP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554262-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Glenmark Pharmaceuticals Limited (IN) | 2005-07-20 | — | — | EP | claimed |
| WO-2004037805-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-05-06 | — | — | WO | claimed |