Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.48 |
| ▸ | PDE4A | P27815 | 5/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472098 | 0.89 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4CGFER | |
| SCHEMBL6472458 | 0.88 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6472450 | 0.83 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6470748 | 0.81 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6470721 | 0.81 | TYK2 (0.51) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6473039 | 0.80 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5016433 | 0.77 | PDE4D (0.58) | PDE4BPDE4DPDE4APDE4CGFER | |
| SCHEMBL6472455 | 0.74 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5025240 | 0.73 | PDE4D (0.53) | PDE4BPDE4DPDE4APDE4CGFER | |
| SCHEMBL6470724 | 0.72 | PDE4B (0.41) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554262-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Glenmark Pharmaceuticals Limited (IN) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004037805-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-05-06 | — | — | WO | disclosed |