Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132147 | 0.92 | HTT (0.41) | HTTSMN1; SMN2OPRK1SIGMAR1ADRB2 | |
| SCHEMBL5132972 | 0.88 | HTT (0.43) | HTTSMN1; SMN2OPRK1SIGMAR1ADRB2 | |
| SCHEMBL5133519 | 0.88 | CPB2 (0.40) | HTTSMN1; SMN2OPRK1SIGMAR1ADRB2 | |
| SCHEMBL5132093 | 0.84 | ADRB2 (0.41) | HTTSMN1; SMN2OPRK1ADRB2ADRB1 | |
| SCHEMBL6470834 | 0.81 | CPB2 (0.42) | SIGMAR1CPB2SLC6A4GABRPGABRD | |
| SCHEMBL5044960 | 0.80 | CPB2 (0.41) | HTTSMN1; SMN2CPB2SLC6A4CYP1A2 | |
| SCHEMBL5037248 | 0.80 | MEN1 (0.40) | HTTSMN1; SMN2OPRK1ADRB2ADRB1 | |
| SCHEMBL5131617 | 0.80 | BCHE (0.58) | SMN1; SMN2OPRK1SIGMAR1CPB2MEN1 | |
| SCHEMBL6470792 | 0.80 | KDM4E (0.45) | HTTSMN1; SMN2OPRK1SIGMAR1ADRB2 | |
| SCHEMBL6469030 | 0.79 | KCNH2 (0.56) | MEN1KMT2AKCNH2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | HTT 6/4885SMN1; SMN2 106/4885OPRK1 1334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.