Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.41 |
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CCR7 | P32248 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30435122 | 1.00 | KMT2A (0.66) | KMT2ASIRT6NNMTKITFLT3 | |
| SCHEMBL2678960 | 0.87 | KMT2A (0.68) | KMT2ASIRT6NNMTKITFLT3 | |
| SCHEMBL2677722 | 0.84 | KMT2A (0.74) | KMT2ASIRT6NNMTKITFLT3 | |
| SCHEMBL19965699 | 0.81 | KMT2A (0.60) | KMT2ASIRT6NNMTKITFLT3 | |
| SCHEMBL19987504 | 0.81 | KMT2A (0.60) | KMT2ASIRT6NNMTKITFLT3 | |
| SCHEMBL1996711 | 0.79 | KMT2A (1.00) | KMT2ASIRT6KITFLT3MAPK1 | |
| SCHEMBL5132154 | 0.78 | KMT2A (0.53) | KMT2ASIRT6TSHRNAMPT | |
| SCHEMBL14574591 | 0.77 | KMT2A (0.40) | KMT2AHCRTR1HCRTR2 | |
| SCHEMBL11533169 | 0.75 | KMT2A (0.62) | KMT2ASIRT6TSHRMAPK1VNN1 | |
| SCHEMBL30595907 | 0.73 | OPRM1 (0.42) | KMT2AADORA3TSHRMC4RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | KMT2A 2085/4885SIRT6 750/4885NNMT 559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.