Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14559577 | 0.80 | ALDH1A1 (0.55) | PDPK1ALDH1A1FLT3CYP1A2MAPK1 | |
| SCHEMBL2343403 | 0.77 | MAPK1 (0.58) | PDPK1FLT3MAPK1MKNK1TTBK1 | |
| SCHEMBL10094590 | 0.77 | PDPK1 (1.00) | PDPK1ALDH1A1CYP1A2MAPK1HPGDS | |
| SCHEMBL4693022 | 0.76 | FLT3 (0.66) | FLT3MAPK1MKNK1TTBK1LMNA | |
| SCHEMBL4691855 | 0.74 | MKNK1 (0.67) | FLT3MAPK1MKNK1CCNT1CCNA2 | |
| SCHEMBL3260279 | 0.74 | MAPK1 (0.51) | PDPK1ALDH1A1FLT3CYP1A2MAPK1 | |
| SCHEMBL14036104 | 0.74 | PDPK1 (0.73) | PDPK1ALDH1A1CYP1A2MAPK1HPGDS | |
| SCHEMBL14559625 | 0.73 | CYP1A2 (0.51) | PDPK1ALDH1A1FLT3CYP1A2MAPK1 | |
| SCHEMBL14827602 | 0.72 | PDPK1 (0.66) | PDPK1ALDH1A1CYP1A2MAPK1HPGDS | |
| SCHEMBL10094121 | 0.72 | PDPK1 (0.66) | PDPK1ALDH1A1CYP1A2MAPK1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050203063-A1 | Proteasome pathway inhibitors and related methods | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203063-A1 | Proteasome pathway inhibitors and related methods | PSME1, PSMC5, PSMB1 | PDPK1 543/4885ALDH1A1 3815/4885FLT3 3376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.