Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3455835 | 0.71 | POLB (1.00) | POLBLMNAMAOBTP53ALDH1A1 | |
| SCHEMBL3837348 | 0.70 | POLB (0.78) | POLBP2RX7LMNAMAOBTP53 | |
| SCHEMBL24896440 | 0.66 | POLB (0.52) | POLBP2RX7LMNAMAOBPTGS2 | |
| SCHEMBL4483267 | 0.66 | P2RX7 (1.00) | POLBP2RX7NPC1ALDH1A1MAPT | |
| SCHEMBL9001638 | 0.66 | POLB (0.75) | POLBLMNAMAOBHTTL3MBTL1 | |
| SCHEMBL6473197 | 0.66 | KDM4E (0.47) | POLBALOX5ALDH1A1KMT2AMEN1 | |
| SCHEMBL3644717 | 0.65 | MAOB (0.56) | POLBLMNAMAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL7560668 | 0.65 | POLB (0.45) | POLBP2RX7LMNAPTGS2ALDH1A1 | |
| SCHEMBL39522 | 0.65 | GRIN2D (0.49) | POLBP2RX7PTGS2GPBAR1KMT2A | |
| SCHEMBL7376466 | 0.65 | POLB (0.67) | POLBP2RX7LMNAMAOBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005018557-A2 | SUBSTITUTED PYRIDINONES | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |