Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 14/20 | 0.62 |
| ▸ | CTSB | P07858 | 7/20 | 0.60 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.58 |
| ▸ | CTSK | P43235 | 2/20 | 0.55 |
| ▸ | CTSS | P25774 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474414 | 0.86 | PTPN1 (0.49) | CTSLCTSB | |
| SCHEMBL3881009 | 0.86 | CTSL (0.62) | CTSLCTSBCTSKCTSS | |
| SCHEMBL10366989 | 0.86 | CTSL (0.62) | CTSLCTSBCTSKCTSS | |
| SCHEMBL30404224 | 0.86 | CTSL (0.62) | CTSLCTSBCTSKCTSS | |
| SCHEMBL6473599 | 0.86 | PPARG (0.52) | CTSLCTSBCTSK | |
| SCHEMBL11746062 | 0.85 | HTR2A (0.60) | CTSLCTSB | |
| 4-Nitrophenyl Acetate SCHEMBL7325115 | 0.85 | CTSL (0.61) | CTSLCTSBCTSKCTSS | |
| SCHEMBL11138908 | 0.84 | CTSL (0.65) | CTSLCTSB | |
| SCHEMBL951558 | 0.84 | CTSL (0.65) | CTSLCTSB | |
| SCHEMBL8713258 | 0.84 | CTSL (0.65) | CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |