Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | APEX1 | P27695 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28446567 | 1.00 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2SRD5A2KMT2ATDP1 | |
| 4-Methylbenzoic Acid SCHEMBL28449050 | 1.00 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2SRD5A2KMT2ATDP1 | |
| 4-Methylbenzoic Acid SCHEMBL28711761 | 0.92 | SMN1; SMN2 (0.65) | ALDH1A1SMN1; SMN2SRD5A2KMT2AMEN1 | |
| SCHEMBL49984 | 0.89 | TSHR (0.63) | ALDH1A1SMN1; SMN2SRD5A2KMT2ATDP1 | |
| Terephthalic Acid SCHEMBL28453225 | 0.89 | TSHR (0.63) | ALDH1A1SMN1; SMN2SRD5A2KMT2ATDP1 | |
| Terephthalic Acid SCHEMBL28358133 | 0.89 | TSHR (0.63) | ALDH1A1SMN1; SMN2SRD5A2KMT2ATDP1 | |
| 4-Methylbenzoic Acid SCHEMBL7126317 | 0.88 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2SRD5A2KMT2ATDP1 | |
| SCHEMBL15251986 | 0.87 | TSHR (0.60) | ALDH1A1SMN1; SMN2SRD5A2KMT2ATDP1 | |
| SCHEMBL10570096 | 0.87 | TSHR (0.60) | ALDH1A1SMN1; SMN2SRD5A2KMT2ATDP1 | |
| Ammonia Solution, Strong SCHEMBL11061336 | 0.87 | TSHR (0.60) | ALDH1A1SMN1; SMN2SRD5A2KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019149-A1 | SYSTEM AND METHOD FOR ACETIC ACID RECOVERY DURING TEREPHTHALIC ACID PRODUCTION | AMT INTERNATIONAL, INC. (US) | 2005-03-03 | — | — | WO | disclosed |