Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6471284 | 0.91 | MEN1 (0.46) | RAB9ATDP1LMNAKMT2AALDH1A1 | |
| SCHEMBL6258578 | 0.88 | ALDH1A1 (0.44) | KMT2AALDH1A1MEN1POLBL3MBTL1 | |
| SCHEMBL6470730 | 0.87 | TP53 (0.48) | TDP1LMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL6258893 | 0.86 | MEN1 (0.42) | RAB9AKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL6476368 | 0.86 | MEN1 (0.44) | KMT2AALDH1A1MEN1POLB | |
| SCHEMBL6473171 | 0.85 | MEN1 (0.41) | RAB9ALMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL7105782 | 0.85 | MEN1 (0.41) | RAB9ALMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL6472338 | 0.85 | MEN1 (0.41) | LMNAKMT2AALDH1A1MEN1POLB | |
| SCHEMBL6260852 | 0.84 | NPSR1 (0.43) | RAB9ALMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL6470949 | 0.82 | POLB (0.42) | RAB9ALMNAKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530475-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 | Warner-Lambert Company LLC (US) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004006931-A2 | PHARMACEUTICAL COMPOSTIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 | WARNER-LAMBERT COMPANY LLC (US) | 2004-01-22 | — | — | WO | disclosed |