Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3001838 | 0.82 | RAB9A (0.51) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL15706264 | 0.81 | TNF (0.53) | TNFNOD1NPC1RAB9AKDM4E | |
| SCHEMBL3589816 | 0.78 | RARA (0.49) | NPC1RAB9AALDH1A1HPGDNPSR1 | |
| SCHEMBL13801076 | 0.76 | TNF (0.59) | TNFNOD1NPC1RAB9AKDM4E | |
| SCHEMBL11527374 | 0.73 | MEN1 (0.49) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL3368282 | 0.73 | MAPT (0.46) | TNFNOD1NPC1RAB9AKDM4E | |
| SCHEMBL4902362 | 0.73 | TNF (0.46) | TNFNOD1NPC1RAB9AKDM4E | |
| SCHEMBL4074932 | 0.73 | TNF (0.56) | TNFNOD1NPC1RAB9AKDM4E | |
| SCHEMBL14062423 | 0.71 | NPC1 (0.75) | TNFNOD1NPC1RAB9AKDM4E | |
| SCHEMBL7805156 | 0.71 | NPC1 (0.75) | TNFNOD1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6930131-B2 | Aryl substituted 3-ethoxy phenyl trifluoromethane sulfonamides for the treatment of non-insulin dependent diabetes mellitus (NIDDM) | WYETH (US) | 2005-08-16 | — | — | US | disclosed |