Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ERN1 | O75460 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1253929 | 0.95 | L3MBTL1 (0.44) | L3MBTL1CA1CA2KMT2AALDH1A1 | |
| SCHEMBL1299322 | 0.90 | ERN1 (0.41) | L3MBTL1CA1CA2KMT2AALDH1A1 | |
| SCHEMBL1254363 | 0.83 | ALDH1A1 (0.43) | L3MBTL1CA1CA2KMT2AALDH1A1 | |
| SCHEMBL5255681 | 0.81 | ERN1 (0.41) | L3MBTL1CA1CA2KMT2AALDH1A1 | |
| SCHEMBL3808547 | 0.78 | KMT2A (0.41) | CA1CA2KMT2AALDH1A1MEN1 | |
| SCHEMBL16958358 | 0.78 | ALDH1A1 (0.48) | L3MBTL1KMT2AALDH1A1MEN1GAA | |
| SCHEMBL16950330 | 0.78 | L3MBTL1 (0.44) | L3MBTL1KMT2AALDH1A1MEN1GAA | |
| SCHEMBL23696963 | 0.78 | ALDH1A1 (0.50) | L3MBTL1KMT2AALDH1A1MEN1GAA | |
| SCHEMBL30304089 | 0.77 | HPGD (0.44) | L3MBTL1CA1CA2KMT2AALDH1A1 | |
| SCHEMBL1547567 | 0.76 | L3MBTL1 (0.59) | L3MBTL1KMT2AALDH1A1MEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575951-A1 | HETEROCYCLIC COMPOUNDS, METHODS OF MAKING THEM AND THEIR USE IN THERAPY | Affinium Pharmaceuticals, Inc. (CA) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004052890-A1 | HETEROCYCLIC COMPOUNDS, METHODS OF MAKING THEM AND THEIR USE IN THERAPY | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2004-06-24 | — | — | WO | disclosed |