Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6470897 | 0.92 | MAPK14 (0.37) | MAPK14MAPK11MEN1KMT2APTGER1 | |
| SCHEMBL6471671 | 0.87 | PTGER1 (0.42) | MAPK14PTGER1 | |
| SCHEMBL6474965 | 0.85 | MAPK14 (0.39) | MAPK14MAPK11P2RX7 | |
| SCHEMBL6471283 | 0.85 | PDE3B (0.37) | MAPK14MAPK11GABRA1PTGER1 | |
| SCHEMBL6474519 | 0.81 | MAPK14 (0.46) | MAPK14MAPK11P2RX7 | |
| SCHEMBL6471970 | 0.81 | MAPK14 (0.44) | MAPK14MAPK11PTGER1P2RX7PSEN1 | |
| SCHEMBL6472626 | 0.80 | MAPK14 (0.40) | MAPK14MAPK11P2RX7 | |
| SCHEMBL6471507 | 0.79 | MAPK14 (0.41) | MAPK14MAPK11 | |
| SCHEMBL4389818 | 0.78 | MAPK14 (0.43) | MAPK14MAPK11P2RX7 | |
| SCHEMBL6471998 | 0.77 | MAPK14 (0.43) | MAPK14MAPK11PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005018557-A2 | SUBSTITUTED PYRIDINONES | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |