Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.44 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.44 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.43 |
| ▸ | CTRL | P40313 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.43 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.43 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.43 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.43 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.43 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.43 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.43 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.43 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6481515 | 0.92 | ITGB1 (0.47) | PSMB8ITGB1ITGA4ITGB7PSMB5 | |
| SCHEMBL6474041 | 0.92 | CTSS (0.45) | EPHX1CTSSCACNA1BPSMB8ITGB1 | |
| SCHEMBL6478996 | 0.90 | CACNA1B (0.47) | CTSSCACNA1BPSMB8ITGB1ITGA4 | |
| SCHEMBL6481231 | 0.90 | ITGB1 (0.46) | CACNA1BITGB1ITGA4ITGB7PSMB5 | |
| SCHEMBL6480784 | 0.90 | CACNA1B (0.47) | CTSSCACNA1BPSMB8ITGB1ITGA4 | |
| SCHEMBL6481964 | 0.90 | ITGB1 (0.45) | CTSSCACNA1BPSMB8ITGB1ITGA4 | |
| SCHEMBL24868206 | 0.89 | ITGB1 (0.50) | PSMB8ITGB1ITGA4ITGB7PSMB5 | |
| SCHEMBL6840497 | 0.89 | MAPK1 (0.45) | PSMB8ITGB1ITGA4ITGB7PSMB5 | |
| SCHEMBL20815350 | 0.89 | MAPK1 (0.45) | PSMB8ITGB1ITGA4ITGB7PSMB5 | |
| SCHEMBL29371746 | 0.89 | MAPK1 (0.45) | PSMB8ITGB1ITGA4ITGB7PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | claimed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | claimed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | claimed |
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |