Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.42 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.42 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | CASP6 | P55212 | 2/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.42 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.41 |
| ▸ | CTRL | P40313 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474049 | 0.90 | EPHX1 (0.46) | CACNA1BITGB1ITGA4ITGB7KMT2A | |
| SCHEMBL6481282 | 0.89 | ITGB1 (0.46) | CACNA1BITGB1ITGA4ITGB7PSMB8 | |
| SCHEMBL6474041 | 0.89 | CTSS (0.45) | CACNA1BITGB1ITGA4ITGB7KMT2A | |
| SCHEMBL6473601 | 0.88 | PSMB11 (0.44) | ITGB1ITGA4ITGB7KMT2AMEN1 | |
| SCHEMBL6478996 | 0.88 | CACNA1B (0.47) | CACNA1BITGB1ITGA4ITGB7KMT2A | |
| SCHEMBL6481964 | 0.87 | ITGB1 (0.45) | CACNA1BITGB1ITGA4ITGB7CTSS | |
| SCHEMBL6481561 | 0.86 | PSMB11 (0.45) | ITGB1ITGA4ITGB7PSMB8CASP3 | |
| SCHEMBL6479150 | 0.85 | CASP1 (0.52) | CACNA1BITGB1ITGA4ITGB7CTSS | |
| SCHEMBL6481551 | 0.84 | SMN1; SMN2 (0.47) | ITGB1ITGA4ITGB7KMT2AMEN1 | |
| SCHEMBL6482015 | 0.84 | TSHR (0.49) | CACNA1BITGB1ITGA4ITGB7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | claimed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | claimed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | claimed |
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |