Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 6/20 | 0.52 |
| ▸ | CTSL | P07711 | 4/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.52 |
| ▸ | YAP1 | P46937 | 3/20 | 0.50 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.48 |
| ▸ | REN | P00797 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474204 | 1.00 | MAPK1 (0.56) | MAPK1CTSKCTSLCACNA1BYAP1 | |
| SCHEMBL6473065 | 0.91 | MAPK1 (0.52) | MAPK1CTSKCTSLCACNA1BYAP1 | |
| SCHEMBL6481485 | 0.89 | CTSK (0.56) | CTSKCTSLCAPN1CTSSP2RX7 | |
| SCHEMBL6479130 | 0.88 | CTSK (0.55) | CTSKCTSLCACNA1BCAPN1CTSS | |
| SCHEMBL6479823 | 0.87 | CTSK (0.54) | CTSKCTSLCACNA1BCAPN1CTSS | |
| SCHEMBL6479164 | 0.85 | CACNA1B (0.50) | MAPK1CACNA1BYAP1REN | |
| SCHEMBL7536860 | 0.85 | CACNA1B (0.50) | MAPK1CACNA1BYAP1REN | |
| Hydrochloric Acid SCHEMBL7540812 | 0.84 | CACNA1B (0.49) | MAPK1CACNA1BYAP1REN | |
| Hydrochloric Acid SCHEMBL6480368 | 0.84 | CACNA1B (0.49) | MAPK1CACNA1BYAP1REN | |
| SCHEMBL10349214 | 0.82 | CTSK (0.69) | CTSKCTSLCTSBCAPN1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |