Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358403 | 1.00 | MAPT (0.61) | MAPTPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL9847265 | 0.97 | MAPT (0.58) | MAPTPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL9362320 | 0.96 | MAPT (0.56) | MAPTPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL9362316 | 0.96 | MAPT (0.56) | MAPTPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL592173 | 0.94 | MAPT (0.55) | MAPTPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL9847275 | 0.94 | MAPT (0.58) | MAPTPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL9358488 | 0.94 | MAPT (0.55) | MAPTPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL592174 | 0.94 | MAPT (0.55) | MAPTPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL9358492 | 0.94 | MAPT (0.55) | MAPTPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL9847350 | 0.93 | MAPT (0.54) | MAPTPTGS2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972287-B1 | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits | PFIZER INC. (US) | 2005-12-06 | — | — | US | disclosed |
| US-20040220235-A1 | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits | AUGELLI-SZAFRAN CORINNE ELIZAB (US) | 2004-11-04 | — | — | US | disclosed |
| EP-1225886-A2 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2000076489-A2 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |
| EP-0418654-B1 | Coupler-type optical switch and process for producing the same | SUMITOMO ELECTRIC INDUSTRIES (JP) | 1994-12-21 | — | — | EP | disclosed |
| EP-0313475-B1 | AN OPTICAL ARTICLE CONTAINING A TRANSMISSION MEDIUM EXHIBITING A HIGH LEVEL OF SECOND ORDER POLARIZATION SUSCEPTIBILITY | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1992-12-23 | — | — | EP | disclosed |
| US-5108200-A | Medium surrounding photocoupler contains optic material who refrative index changes by action of electric or magnetic field | SUMITOMO ELECTRIC INDUSTRIES LTD. (JP) | 1992-04-28 | — | — | US | disclosed |
| EP-0418654-A1 | Coupler-type optical switch and process for producing the same | SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |
| US-4886339-A | MOLECULAR DIPOLES HELD IN POLAR ALIGNMENT BY A CROSSLINKED POLYMERIC BINDER; STABILITY | EASTMAN KODAK COMPANY (US) | 1989-12-12 | — | — | US | disclosed |
| EP-0313475-A2 | An optical article containing a transmission medium exhibiting a high level of second order polarization susceptibility | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1989-04-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220235-A1 | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits | APP, PSEN1, BACE1 | MAPT 6/4885PTGS2 3460/4885ALDH1A1 2945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.