Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | GABRP | O00591 | 2/20 | 0.34 |
| ▸ | GABRD | O14764 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6061965 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL10667290 | 0.87 | — | — | |
| Vigabatrin SCHEMBL31159534 | 0.76 | — | — | |
| Vigabatrin SCHEMBL5785801 | 0.76 | CYP2D6 (1.00) | SLC6A2SLC6A4BLMSLC6A3MEN1 | |
| Vigabatrin SCHEMBL26714 | 0.76 | — | — | |
| Vigabatrin SCHEMBL9132153 | 0.76 | — | — | |
| Vigabatrin SCHEMBL465981 | 0.76 | — | — | |
| SCHEMBL6576182 | 0.75 | — | — | |
| SCHEMBL9635455 | 0.74 | BLM (0.59) | SLC6A2SLC6A4BLMSLC6A3MEN1 | |
| Vigabatrin SCHEMBL20659806 | 0.74 | CYP2D6 (0.95) | SLC6A2SLC6A4BLMSLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119799-B2 | Method for the production of polyisocyanates comprising isocyanurate groups and use therof | BASF AKTIENGESELLSCHAFT (DE) | 2012-02-21 | — | — | US | disclosed |
| US-20070197759-A1 | Method for the production of polyisocyanates comprising isocyanurate groups and use therof | BASF AKTIENGESELLSCHAFT (DE) | 2007-08-23 | — | — | US | disclosed |