Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.48 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.48 |
| ▸ | GSR | P00390 | 2/20 | 0.48 |
| ▸ | GRM8 | O00222 | 1/20 | 0.48 |
| ▸ | GRM6 | O15303 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635451 | 1.00 | BLM (0.59) | BLMKMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8068164 | 0.80 | GSR (0.68) | BLMKMT2AGRIK1GRIK2GSR | |
| SCHEMBL602426 | 0.80 | GSR (0.68) | BLMKMT2AGRIK1GRIK2GSR | |
| SCHEMBL31556203 | 0.79 | GSR (0.50) | BLMKMT2AGRIK1GRIK2GSR | |
| Hydrochloric Acid SCHEMBL11780148 | 0.77 | GSR (0.65) | BLMKMT2AGRIK1GRIK2GSR | |
| SCHEMBL9635488 | 0.77 | GSR (0.43) | BLMKMT2AGRIK1GRIK2GSR | |
| SCHEMBL10657241 | 0.75 | GRIK1 (0.42) | BLMKMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10657720 | 0.75 | GRIK1 (0.42) | BLMKMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24323664 | 0.74 | — | — | |
| SCHEMBL865052 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0326766-B1 | 5-SUBSTITUTED ORNITHINE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4902719-A | ORNITHINE DEFICIENCY TREATMENT | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0326766-A1 | 5-Substituted ornithine derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-08-09 | — | — | EP | disclosed |