Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
| ▸ | FNTB | P49356 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27787627 | 0.87 | ALDH1A1 (0.48) | KMT2AMEN1ALDH1A1CNR1CNR2 | |
| SCHEMBL4447625 | 0.87 | KMT2A (0.47) | KMT2AMEN1ALDH1A1TDP1CNR1 | |
| SCHEMBL1857061 | 0.87 | FNTA (0.58) | KMT2AMEN1ALDH1A1TDP1NPC1 | |
| SCHEMBL7561593 | 0.86 | FAAH (0.52) | KMT2AMEN1ALDH1A1NPC1MAPT | |
| SCHEMBL12814969 | 0.85 | ALDH1A1 (0.64) | KMT2AMEN1ALDH1A1TDP1CNR1 | |
| SCHEMBL6554210 | 0.84 | KMT2A (0.55) | KMT2AMEN1ALDH1A1TDP1MAPT | |
| SCHEMBL3714135 | 0.84 | FFAR1 (0.53) | KMT2AMEN1ALDH1A1TDP1NPC1 | |
| SCHEMBL10346999 | 0.84 | ALDH1A1 (0.49) | KMT2AMEN1ALDH1A1TDP1CNR1 | |
| SCHEMBL2452348 | 0.84 | ALDH1A1 (0.49) | KMT2AMEN1ALDH1A1TDP1CNR1 | |
| SCHEMBL7105979 | 0.84 | ALDH1A1 (0.49) | KMT2AMEN1ALDH1A1TDP1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894052-B1 | Serotonergic receptor antagonist | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2005-05-17 | — | — | US | disclosed |
| EP-1000046-B1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI CHEM PHARM (CH) | 2003-11-26 | — | — | EP | disclosed |
| US-6218167-B1 | NUCLEIC ACID SEQUENCE ENCODING ESTERASE ENZYMES CHARACTERIZED BY THE ABILITY TO REMAIN STABLE AT CERTAIN TEMPERATURES, SUBSTRATE SPECIFICITIES, AND ACTIVITY PROFILE; CELLS TRANSFORMED WITH NUCLEIC ACID | THERMOGEN, INC. | 2001-04-17 | — | — | US | disclosed |
| EP-1005556-A2 | STABLE BIOCATALYSTS FOR ESTER HYDROLYSIS | Thermogen, Inc. (US) | 2000-06-07 | — | — | EP | disclosed |
| WO-1998046770-A9 | STABLE BIOCATALYSTS FOR ESTER HYDROLYSIS | — | 1999-03-18 | — | — | WO | disclosed |
| WO-1998046770-A2 | STABLE BIOCATALYSTS FOR ESTER HYDROLYSIS | THERMOGEN, INC. (US) | 1998-10-22 | — | — | WO | disclosed |