Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Enviroxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 18/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Viroxime SCHEMBL3586 | 0.86 | PI4KB (1.00) | PI4KBMAPK14CYP3A4 | |
| Zinviroxime SCHEMBL149064 | 0.86 | PI4KB (1.00) | PI4KBMAPK14CYP3A4 | |
| Enviroxime SCHEMBL3585 | 0.86 | PI4KB (1.00) | PI4KBMAPK14CYP3A4 | |
| Viroxime SCHEMBL29365398 | 0.86 | PI4KB (1.00) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL10906292 | 0.75 | PI4KB (0.74) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL4837467 | 0.75 | PI4KB (0.74) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL11149101 | 0.73 | PI4KB (0.71) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL11148839 | 0.72 | PI4KB (0.70) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL11073939 | 0.72 | PI4KB (0.72) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL11150109 | 0.72 | PI4KB (0.69) | PI4KBMAPK14CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974802-B2 | Treatment of viral infections using prodrugs of 2′,3-dideoxy,3′-fluoroguanosine | MEDIVIR AB (SE) | 2005-12-13 | — | — | US | disclosed |
| US-6458772-B1 | Prodrugs | MEDIVIR AB (SE) | 2002-10-01 | — | — | US | disclosed |
| EP-1054891-A1 | PRODRUGS | MEDIVIR AB (SE) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041275-A1 | PRODRUGS | MEDIVIR AB (SE) | 1999-08-19 | — | — | WO | disclosed |