Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 8/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 5/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 4/20 | 0.34 |
| ▸ | PLAT | P00750 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475411 | 0.86 | AR (0.37) | F10ROCK2MAPK8 | |
| SCHEMBL6482506 | 0.81 | HAO1 (0.44) | HAO1PTGER4PTGER2 | |
| SCHEMBL6484313 | 0.80 | SRD5A2 (0.38) | — | |
| SCHEMBL6482198 | 0.72 | HPGD (0.43) | MAPK8 | |
| SCHEMBL6483899 | 0.71 | SMN1; SMN2 (0.41) | ROCK2MAPK8PTGER4PTGER2 | |
| SCHEMBL6476121 | 0.71 | PDE4A (0.44) | PTGER4PTGER2 | |
| SCHEMBL6474340 | 0.69 | AR (0.39) | PTGER4PTGER2NOS1NOS2 | |
| SCHEMBL6474823 | 0.69 | FNTA (0.45) | F10 | |
| SCHEMBL28091937 | 0.68 | CA2 (0.46) | MAPK8 | |
| SCHEMBL5373538 | 0.67 | MAPK8 (0.50) | MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869945-B2 | Pyrrolyl-and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes | PFIZER INC (US) | 2005-03-22 | — | — | US | disclosed |