⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7546724 | 0.83 | ALDH1A1 (0.45) | — | |
| SCHEMBL10884319 | 0.82 | — | — | |
| SCHEMBL7101023 | 0.80 | ALDH1A1 (0.43) | — | |
| SCHEMBL12852155 | 0.80 | ALDH1A1 (0.43) | — | |
| SCHEMBL9077135 | 0.78 | ALDH1A1 (0.41) | — | |
| SCHEMBL8096104 | 0.78 | — | — | |
| SCHEMBL11313394 | 0.78 | — | — | |
| SCHEMBL7840618 | 0.77 | HTT (0.43) | — | |
| SCHEMBL7056843 | 0.72 | — | — | |
| SCHEMBL5892263 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956037-B2 | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRAZENECA AB (SE) | 2005-10-18 | — | — | US | disclosed |
| EP-1077931-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-17 | — | — | EP | disclosed |
| US-6579872-B1 | Such as TNF, in particular of TNF alpha, and various interleukins, in particular IL-1; N-(5-(4-(3-hydroxypropoxy)benzamido)-2-methylphenyl)-3,4-dimethoxybenzamide | ASTRAZENECA AB (SE) | 2003-06-17 | — | — | US | disclosed |
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |
| US-5457105-A | anticancer use; e.g. 4-(3'-chloro-4'-fluoroanilino)-6,7-dimethoxyquinazoline (gefitinib) | ZENECA LIMITED (GB) | 1995-10-10 | — | — | US | disclosed |
| EP-0566226-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1993-10-20 | — | — | EP | disclosed |
| EP-0099535-B1 | CYCLOHEXANE-1,3-DIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HERBICIDES | BASF Aktiengesellschaft (DE) | 1986-10-22 | — | — | EP | disclosed |
| US-4517013-A | HERBICIDES, ALKOXYAMINOALKYLIDENE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1985-05-14 | — | — | US | disclosed |
| EP-0099535-A2 | Cyclohexane-1,3-dione derivatives, their preparation and their use as herbicides | BASF Aktiengesellschaft (DE) | 1984-02-01 | — | — | EP | disclosed |