Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 15/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.41 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473186 | 0.87 | FKBP1A (0.48) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL8464222 | 0.86 | FKBP1A (0.48) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL6471963 | 0.84 | FKBP1A (0.53) | FKBP1AFKBP4FKBP5 | |
| SCHEMBL3679356 | 0.80 | FKBP1A (0.60) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL3679353 | 0.80 | FKBP1A (0.60) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL27472326 | 0.80 | FKBP1A (0.51) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL27486132 | 0.79 | FKBP1A (0.49) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL8465804 | 0.77 | FKBP1A (0.53) | FKBP1AMTORFKBP4FKBP5 | |
| SCHEMBL7876164 | 0.75 | UTS2R (0.48) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL7876167 | 0.75 | UTS2R (0.48) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941113-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | Vertex Pharmaceuticals Incorporated (US) | 1999-09-15 | — | — | EP | claimed |
| WO-1998020893-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-05-22 | — | — | WO | claimed |
| WO-2005007162-A1 | COMPOUNDS AUGMENTING THE ACTIVITY OF ANTIBACTERIAL AGENTS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |
| EP-0754176-A1 | NOVEL CARBAMATES AND UREAS AS MODIFIERS OF MULTI-DRUG RESISTANCE | Vertex Pharmaceuticals Incorporated (US) | 1997-01-22 | — | — | EP | disclosed |
| WO-1995026337-A1 | NOVEL CARBAMATES AND UREAS AS MODIFIERS OF MULTI-DRUG RESISTANCE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1995-10-05 | — | — | WO | disclosed |