SCHEMBL6477797

SCHEMBL6477797

NC1[C@H]2CN(c3c(F)cc(N4C[C@H](CNC(=O)C5CC5)OC4=O)cc3F)C[C@@H]12

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.59
F10 P00742 13/20 0.48
MAOA P21397 4/20 0.45
LMNA P02545 1/20 0.45
PTGS1 P23219 1/20 0.45
CALML3 P27482 1/20 0.45
SDHA P31040 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6478267 0.88 F10 (0.48) MAOBF10MAOALMNAPTGS1
SCHEMBL24170013 0.88 MAOB (0.61) MAOBF10MAOALMNAPTGS1
SCHEMBL6336349 0.88 MAOA (0.58) MAOBF10MAOALMNAPTGS1
SCHEMBL6477630 0.88 MAOA (0.58) MAOBF10MAOALMNAPTGS1
SCHEMBL18408756 0.88 MAOB (0.61) MAOBF10MAOALMNAPTGS1
Hydrochloric Acid SCHEMBL6488141 0.87 MAOA (0.57) MAOBF10MAOALMNAPTGS1
SCHEMBL6478284 0.86 F10 (0.46) MAOBF10MAOALMNAPTGS1
Hydrochloric Acid SCHEMBL6488701 0.85 F10 (0.45) MAOBF10MAOALMNAPTGS1
SCHEMBL6489236 0.85 F10 (0.47) MAOBF10MAOALMNAPTGS1
SCHEMBL18408943 0.85 MAOB (0.77) MAOBF10MAOALMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6875784-B2 Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives PHARMACIA & UPJOHN COMPANY (US) 2005-04-05 US disclosed
US-20040127530-A1 Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives PHARMACIA & UPJOHN COMPANY 2004-07-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040127530-A1 Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives OXA1L, CYP1B1, MT-CO1 MAOB 739/4885F10 1247/4885MAOA 743/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.