Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 5/20 | 0.48 |
| ▸ | IDH1 | O75874 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480232 | 0.90 | TRPV1 (0.62) | TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6489077 | 0.85 | TRPV1 (0.74) | TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6488133 | 0.85 | CNR1 (0.64) | TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6478899 | 0.81 | TRPV1 (0.59) | TRPV1MEN1KMT2ASMN1; SMN2CNR1 | |
| SCHEMBL6479587 | 0.81 | TRPV1 (0.56) | TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23831812 | 0.80 | TRPV1 (0.63) | TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30792273 | 0.80 | TRPV1 (0.63) | TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23831565 | 0.80 | TRPV1 (0.62) | TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6489149 | 0.79 | TRPV1 (0.59) | TRPV1MEN1KMT2AALDH1A1CNR1 | |
| SCHEMBL6490705 | 0.79 | TRPV1 (0.58) | TRPV1MEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050154230-A1 | Urea derivatives | BAYER HEALTHCARE AG (DE) | 2005-07-14 | — | — | US | claimed |
| US-20050154230-A1 | Urea derivatives | BAYER HEALTHCARE AG (DE) | 2005-07-14 | — | — | US | disclosed |
| EP-1461311-A2 | UREA DERIVATIVES AS VR1-ANTAGONISTS | Bayer HealthCare AG (DE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003055848-A2 | UREA DERIVATIVES AS VR1- ANTAGONISTS | BAYER HEALTHCARE AG (DE) | 2003-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154230-A1 | Urea derivatives | SLC14A1, UBA1, VAT1 | TRPV1 214/4885MEN1 4397/4885KMT2A 3964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.