Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 8/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 8/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | IDE | P14735 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649169 | 1.00 | C5AR1 (0.40) | C5AR1UBE2MDCUN1D1ADORA1KMT2A | |
| SCHEMBL647784 | 0.91 | C5AR1 (0.39) | C5AR1UBE2MDCUN1D1ADORA1TRPV4 | |
| SCHEMBL651973 | 0.91 | C5AR1 (0.39) | C5AR1UBE2MDCUN1D1ADORA1TRPV4 | |
| SCHEMBL1912913 | 0.85 | C5AR1 (0.40) | C5AR1ADORA1ADORA2B | |
| SCHEMBL650465 | 0.85 | C5AR1 (0.40) | C5AR1ADORA1ADORA2B | |
| SCHEMBL1912909 | 0.84 | C5AR1 (0.61) | C5AR1UBE2MDCUN1D1 | |
| SCHEMBL648047 | 0.84 | C5AR1 (0.61) | C5AR1UBE2MDCUN1D1 | |
| SCHEMBL650435 | 0.83 | C5AR1 (0.42) | C5AR1UBE2MDCUN1D1ADORA1KMT2A | |
| SCHEMBL650033 | 0.83 | C5AR1 (0.39) | C5AR1ADORA1ADORA2BMDM2 | |
| SCHEMBL648055 | 0.83 | C5AR1 (0.39) | C5AR1ADORA1ADORA2BMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |