Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479046 | 1.00 | ADORA2B (0.37) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6351111 | 0.87 | TNF (0.36) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6351110 | 0.87 | TNF (0.36) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28636619 | 0.72 | ADORA2B (0.41) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6346603 | 0.71 | TNF (0.37) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6346602 | 0.71 | TNF (0.37) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6355685 | 0.70 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL6355684 | 0.70 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL6189309 | 0.70 | ADORA2B (0.49) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14057491 | 0.70 | LGMN (0.41) | ADORA2BPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878715-B1 | Therapeutic compounds for inhibiting interleukin-12 signals and method for using same | CELL THERAPEUTICS, INC. (US) | 2005-04-12 | — | — | US | disclosed |