Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.31 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | TACR2 | P21452 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7171788 | 0.98 | PPARA (0.39) | PPARAKCNH2MAPTPTGS2CYP3A4 | |
| SCHEMBL27745207 | 0.72 | — | — | |
| SCHEMBL5546235 | 0.65 | MAPT (0.33) | PPARAKCNH2MAPTPTGS2CYP3A4 | |
| SCHEMBL3242083 | 0.65 | MAPT (0.39) | KCNH2MAPTTDP1L3MBTL1PTGS2 | |
| SCHEMBL5175178 | 0.65 | CYP1A2 (0.42) | PPARAKCNH2MAPTTDP1L3MBTL1 | |
| SCHEMBL3394938 | 0.64 | EPHX2 (0.54) | KCNH2MAPTPTGS2CYP3A4CHRM2 | |
| SCHEMBL5545188 | 0.64 | MAPT (0.35) | PPARAKCNH2MAPTPTGS2CYP3A4 | |
| SCHEMBL369102 | 0.64 | PPARA (0.71) | PPARAKCNH2MAPTPTGS2CYP3A4 | |
| SCHEMBL263464 | 0.64 | MAPT (0.41) | KCNH2MAPTPTGS2CYP3A4CHRM2 | |
| SCHEMBL22129744 | 0.64 | MAPT (0.41) | KCNH2MAPTPTGS2CYP3A4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897198-B2 | Method of treatment with combinations of statin and aryl-substituted propanolamine derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH | 2005-05-24 | — | — | US | disclosed |
| US-6569835-B2 | Hypolipidemics; treating obesity and disorders of lipid metabolism | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-05-27 | — | — | US | disclosed |
| US-6566340-B2 | Antilipemic agents | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-05-20 | — | — | US | disclosed |
| US-6303639-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERLIPIDEMIA, ARTERIOSCLEROTIC SYMPTOMS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-10-16 | — | — | US | disclosed |
| US-6245744-B1 | ANTILIPEMIC AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-06-12 | — | — | US | disclosed |