Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 15/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 14/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 14/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6477737 | 0.89 | ITGAL (0.43) | ITGALITGB2ICAM1GCGR | |
| SCHEMBL6530585 | 0.88 | ITGAL (0.44) | ITGALITGB2ICAM1 | |
| SCHEMBL6530588 | 0.88 | ITGAL (0.44) | ITGALITGB2ICAM1 | |
| SCHEMBL4848413 | 0.83 | ITGAL (0.48) | ITGALITGB2ICAM1 | |
| SCHEMBL6478538 | 0.83 | ITGAL (0.48) | ITGALITGB2ICAM1 | |
| SCHEMBL4844861 | 0.76 | METAP2 (0.39) | GCGR | |
| SCHEMBL4840120 | 0.75 | ITGAL (0.52) | ITGALITGB2ICAM1 | |
| SCHEMBL4847894 | 0.75 | ITGAL (0.52) | ITGALITGB2ICAM1 | |
| SCHEMBL4849061 | 0.75 | ITGAL (0.52) | ITGALITGB2ICAM1 | |
| SCHEMBL4840098 | 0.75 | ITGAL (0.48) | ITGALITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897225-B1 | Inhibitors of αLβ2 mediated cell adhesion | TANABE SEIYAKU CO., LTD. (JP) | 2005-05-24 | — | — | US | disclosed |