Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6493311 | 0.85 | MAPK1 (0.44) | CNR2SMN1; SMN2GAAMAPK1PKM | |
| SCHEMBL6479785 | 0.85 | MAPK1 (0.44) | CNR2SMN1; SMN2GAAMAPK1PKM | |
| SCHEMBL5851398 | 0.81 | ALDH1A1 (0.54) | SMN1; SMN2MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL6479700 | 0.78 | SMN1; SMN2 (0.58) | CNR2SMN1; SMN2GAAPKMALDH1A1 | |
| SCHEMBL19073863 | 0.77 | NOS2 (0.55) | CNR2ADORA2ASMN1; SMN2PTPN2PTPN1 | |
| SCHEMBL15471712 | 0.77 | CNR2 (0.46) | CNR2ADORA2ASMN1; SMN2PTPN2PTPN1 | |
| SCHEMBL7762123 | 0.74 | HTT (0.59) | SMN1; SMN2GAAMAPK1PKMALDH1A1 | |
| SCHEMBL12026134 | 0.74 | MAPK1 (0.61) | CNR2SMN1; SMN2MAPK1ALDH1A1HTT | |
| SCHEMBL3968378 | 0.74 | CNR2 (0.52) | CNR2ADORA2ASMN1; SMN2PTPN2PTPN1 | |
| SCHEMBL10247393 | 0.74 | HSD17B10 (0.53) | SMN1; SMN2GAAMAPK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962938-B2 | Spiro-cyclic β-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-11-08 | — | — | US | disclosed |
| US-6720329-B2 | ANTIINFLAMMATORY AGENTS | BRISTOL-MYERS SQUIBB PHARMA | 2004-04-13 | — | — | US | disclosed |