Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 3/20 | 0.57 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755119 | 0.78 | HSP90AA1 (0.57) | ITKPIP5K1CKDM4ESMN1; SMN2 | |
| SCHEMBL2735969 | 0.76 | CA12 (0.72) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL6415974 | 0.75 | ITK (0.62) | ITKPIP5K1C | |
| SCHEMBL29114944 | 0.75 | ALDH1A1 (0.53) | KDM4EMMP13ALDH1A1HPGDCYP1A2 | |
| SCHEMBL29115001 | 0.75 | CYP1A2 (0.53) | MMP13ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL34468710 | 0.73 | KDM4E (0.64) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL29114965 | 0.71 | DYRK1A (0.51) | MMP13CYP2C19SMN1; SMN2 | |
| SCHEMBL8211246 | 0.71 | NAMPT (0.51) | ALDH1A1HPGDCA1CA2SMN1; SMN2 | |
| SCHEMBL6479947 | 0.71 | PIP5K1C (0.49) | ITKPIP5K1CCNR2 | |
| SCHEMBL15606227 | 0.70 | CNR2 (0.48) | MMP13PDE2ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K9, MAP3K20, MAP3K19 | ITK 392/4885PIP5K1C 70/4885KDM4E 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.