Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 11/20 | 0.62 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.52 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.45 |
| ▸ | MELK | Q14680 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6413156 | 0.84 | KDR (0.66) | ITKKDRCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL12895651 | 0.82 | ITK (0.48) | ITKKDRFGFR1 | |
| SCHEMBL6410583 | 0.78 | CLK2 (0.49) | ITKPIP5K1CMAPK1AURKACLK2 | |
| SCHEMBL27218186 | 0.77 | KDR (0.67) | KDRCSNK2A2CSNK2BCSNK2A1PLK1 | |
| SCHEMBL6479952 | 0.75 | ITK (0.57) | ITKPIP5K1C | |
| SCHEMBL6414576 | 0.71 | KDR (0.50) | KDRCSNK2A2CSNK2BCSNK2A1PLK1 | |
| SCHEMBL2418622 | 0.71 | KDR (0.53) | KDRCSNK2A2CSNK2BCSNK2A1PLK1 | |
| SCHEMBL2414645 | 0.71 | KDR (0.53) | KDRCSNK2A2CSNK2BCSNK2A1PLK1 | |
| SCHEMBL5755119 | 0.70 | HSP90AA1 (0.57) | ITKPIP5K1CGSK3B | |
| SCHEMBL6410524 | 0.70 | ITK (0.52) | ITKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026984-A1 | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products | AVENTIS PHARMA S.A. (FR) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026984-A1 | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products | TPMT, PARK7, PRNP | ITK 2307/4885KDR 3206/4885CSNK2A2 2270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.