Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | CDC25B | P30305 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755860 | 1.00 | KMT2A (0.53) | KMT2AALDH1A1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL5751505 | 0.75 | MAPT (0.48) | KMT2AALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5754707 | 0.75 | MAPT (0.48) | KMT2AALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL921752 | 0.74 | KMT2A (0.53) | KMT2AALDH1A1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL7808621 | 0.71 | SMN1; SMN2 (0.70) | KMT2AALDH1A1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL22062005 | 0.71 | KMT2A (0.55) | KMT2AALDH1A1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL7672431 | 0.71 | ALDH1A1 (0.55) | KMT2AALDH1A1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL584215 | 0.71 | KMT2A (0.65) | KMT2AALDH1A1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL561497 | 0.70 | CYP1A2 (0.56) | KMT2AALDH1A1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL922022 | 0.70 | SMN1; SMN2 (0.53) | KMT2AALDH1A1TSHRSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K9, MAP3K20, MAP3K19 | KMT2A 1158/4885ALDH1A1 2469/4885TSHR 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.