Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KISS1R | Q969F8 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480432 | 0.87 | KISS1R (0.49) | KMT2AMEN1NPSR1ALDH1A1HTT | |
| SCHEMBL6478801 | 0.86 | ADORA3 (0.49) | KMT2AMEN1NPSR1ALDH1A1HPGD | |
| SCHEMBL6487837 | 0.85 | ADORA3 (0.47) | KMT2AMEN1NPSR1ALDH1A1HPGD | |
| SCHEMBL5224669 | 0.81 | MEN1 (0.49) | KMT2AMEN1NPSR1ALDH1A1HPGD | |
| SCHEMBL6481655 | 0.77 | MEN1 (0.45) | KMT2AMEN1NPSR1PKMALDH1A1 | |
| SCHEMBL6480107 | 0.76 | ADORA3 (0.46) | KMT2AMEN1ALDH1A1HPGDTSHR | |
| Ammonia Solution, Strong SCHEMBL27531632 | 0.74 | KISS1R (0.49) | KMT2AMEN1NPSR1ALDH1A1HPGD | |
| SCHEMBL3520995 | 0.74 | KMT2A (0.54) | KMT2AMEN1NPSR1ALDH1A1HPGD | |
| SCHEMBL5224949 | 0.74 | ADORA3 (0.48) | KMT2AMEN1NPSR1PKMHPGD | |
| SCHEMBL6487647 | 0.72 | MEN1 (0.54) | KMT2AMEN1PKMALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390349-B1 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | SANOFI SA (FR) | 2012-07-25 | — | — | EP | claimed |
| US-6969723-B2 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands | SANOFI - AVENTIS (FR) | 2005-11-29 | — | — | US | claimed |
| US-20040186133-A1 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands | SANOFI (FR) | 2004-09-23 | — | — | US | claimed |
| EP-1390349-A1 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | Sanofi-Aventis (FR) | 2004-02-25 | — | — | EP | claimed |
| WO-2002096879-A9 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | SANOFI SYNTHELABO (FR) | 2003-11-20 | — | — | WO | claimed |
| WO-2002096879-A1 | AMINOQUINOLINE AND AMINOPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS | SANOFI-SYNTHELABO (FR) | 2002-12-05 | — | — | WO | claimed |
| US-20050119343-A1 | Dihydroxy open-acid salt of simvastatin | TILLYER RICHARD D (US) | 2005-06-02 | — | — | US | disclosed |
| EP-1324972-A4 | DIHYDROXY OPEN-ACID SALT OF SIMVASTATIN | MERCK & CO INC (US) | 2004-06-30 | — | — | EP | disclosed |
| US-20030211151-A1 | Dihydroxy open-acid and salts of HMG-Co-A reductase inhibitors | MERCK & CO., INC. | 2003-11-13 | — | — | US | disclosed |
| US-20030176501-A1 | Dihydroxy open-acid salt of simvastatin | TILLYER RICHARD D (US) | 2003-09-18 | — | — | US | disclosed |
| EP-1324972-A1 | DIHYDROXY OPEN-ACID SALT OF SIMVASTATIN | Merck & Co., Inc. (US) | 2003-07-09 | — | — | EP | disclosed |
| US-6569461-B1 | Dihydroxy open acid forms of lovastatin, simvastatin, pravastatin and atorvastatin; enteric coated dosage form; substantial release after oral administration is delayed until after passage through the stomach | MERCK & CO., INC. | 2003-05-27 | — | — | US | disclosed |
| EP-1036783-B1 | Crystalline hydrated dihydroxy open-acid simvastatin calcium salt | MERCK & CO INC (US) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002020457-A1 | DIHYDROXY OPEN-ACID SALT OF SIMVASTATIN | MERCK & CO., INC. (US) | 2002-03-14 | — | — | WO | disclosed |
| EP-1163203-A1 | CRYSTALLINE HYDRATED DIHYDROXY OPEN-ACID SIMVASTATIN CALCIUM SALT | Merck & Co., Inc. (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-1161236-A1 | DIHYDROXY OPEN-ACID AND SALTS OF HMG-CO-A REDUCTASE INHIBITORS | Merck & Co., Inc. (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-1036783-A1 | Crystalline hydrated dihydroxy open-acid simvastatin calcium salt | MERCK & CO. INC. (US) | 2000-09-20 | — | — | EP | disclosed |
| EP-1036563-A1 | Delayed-release oral formulation of dihydroxy open acid simvastatin and salts and esters thereof | MERCK & CO. INC. (US) | 2000-09-20 | — | — | EP | disclosed |
| WO-2000053566-A1 | CRYSTALLINE HYDRATED DIHYDROXY OPEN-ACID SIMVASTATIN CALCIUM SALT | MERCK & CO., INC. (US) | 2000-09-14 | — | — | WO | disclosed |
| WO-2000053173-A1 | DIHYDROXY OPEN-ACID AND SALTS OF HMG-CO-A REDUCTASE INHIBITORS | MERCK & CO., INC. (US) | 2000-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119343-A1 | Dihydroxy open-acid salt of simvastatin | HMGCR, DHCR7, CYP46A1 | KMT2A 2677/4885MEN1 997/4885NPSR1 1379/4885 |
| US-20030211151-A1 | Dihydroxy open-acid and salts of HMG-Co-A reductase inhibitors | HMGCR, CYP46A1, DHCR7 | KMT2A 1743/4885MEN1 2104/4885NPSR1 745/4885 |
| US-20040186133-A1 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands | ADORA3, ADORA1, ADORA2A | KMT2A 2739/4885MEN1 3078/4885NPSR1 568/4885 |
| US-20030176501-A1 | Dihydroxy open-acid salt of simvastatin | HMGCR, DHCR7, CYP46A1 | KMT2A 2677/4885MEN1 997/4885NPSR1 1379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.