Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | YAP1 | P46937 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 3/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.40 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.40 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.40 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.40 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7539927 | 0.92 | MAPK1 (0.44) | MAPK1YAP1CASP3ITGB1ITGA4 | |
| SCHEMBL6481324 | 0.92 | MAPK1 (0.44) | MAPK1YAP1CASP3ITGB1ITGA4 | |
| SCHEMBL598356 | 0.91 | MAPK1 (0.45) | MAPK1YAP1CASP3UBE2NITGB1 | |
| SCHEMBL20815350 | 0.91 | MAPK1 (0.45) | MAPK1YAP1CASP3UBE2NITGB1 | |
| SCHEMBL29371746 | 0.91 | MAPK1 (0.45) | MAPK1YAP1CASP3UBE2NITGB1 | |
| SCHEMBL23230085 | 0.91 | MAPK1 (0.45) | MAPK1YAP1CASP3UBE2NITGB1 | |
| SCHEMBL6840497 | 0.91 | MAPK1 (0.45) | MAPK1YAP1CASP3UBE2NITGB1 | |
| SCHEMBL6474215 | 0.91 | ITGB1 (0.46) | MAPK1YAP1CASP3ITGB1ITGA4 | |
| SCHEMBL6480791 | 0.90 | YAP1 (0.46) | MAPK1YAP1CASP3ITGB1ITGA4 | |
| SCHEMBL22023402 | 0.90 | MAPK1 (0.44) | MAPK1YAP1CASP3UBE2NITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | claimed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | claimed |
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |