SCHEMBL6481040

SCHEMBL6481040

CCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2sccc21

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
F2 P00734 1/20 0.52
LMNA P02545 2/20 0.49
MAPT P10636 2/20 0.49
TP53 P04637 1/20 0.46
GAA P10253 1/20 0.46
RECQL P46063 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
ATM Q13315 1/20 0.46
NR3C1 P04150 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6710942 0.83 KMT2A (0.56) MEN1KMT2AF2LMNAMAPT
SCHEMBL6336396 0.75 MEN1 (0.46) MEN1KMT2AF2LMNATP53
SCHEMBL6708160 0.74 MEN1 (0.57) MEN1KMT2AF2
SCHEMBL1497913 0.74 CNR2 (0.39) MEN1KMT2AGAA
SCHEMBL6707968 0.74 MEN1 (0.56) MEN1KMT2AF2
SCHEMBL20674231 0.73 LMNA (0.43) MEN1KMT2ALMNAMAPT
SCHEMBL6363865 0.73 KCNH2 (0.58) MEN1KMT2A
SCHEMBL6362900 0.73 KCNH2 (0.58)
SCHEMBL6281301 0.72 KMT2A (0.56) MEN1KMT2AF2LMNAMAPT
SCHEMBL23937800 0.71 NR4A2 (0.40) MEN1KMT2ALMNAMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6861438-B2 Antiviral agents PFIZER (US) 2005-03-01 US claimed
EP-1467999-A1 OXOTHIENO[3,2-B]PYRIDINECARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2004-10-20 EP claimed
US-20040138449-A1 Antiviral agents PHARMACIA & UPJOHN COMPANY 2004-07-15 US claimed
WO-2003059912-A1 OXOTHIENO (3, 2-B) PYRIDINECARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2003-07-24 WO claimed
US-6861438-B2 Antiviral agents PFIZER (US) 2005-03-01 US disclosed
US-20040138449-A1 Antiviral agents PHARMACIA & UPJOHN COMPANY 2004-07-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040138449-A1 Antiviral agents IRF3, IFNAR1, EIF2AK2 MEN1 1116/4885KMT2A 2020/4885F2 3230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.