Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 2/20 | 0.42 |
| ▸ | PSMB11 | A5LHX3 | 4/20 | 0.41 |
| ▸ | PSMA7 | O14818 | 4/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.41 |
| ▸ | PSMA1 | P25786 | 4/20 | 0.41 |
| ▸ | PSMA2 | P25787 | 4/20 | 0.41 |
| ▸ | PSMA3 | P25788 | 4/20 | 0.41 |
| ▸ | PSMA4 | P25789 | 4/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.41 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.41 |
| ▸ | PSMA5 | P28066 | 4/20 | 0.41 |
| ▸ | PSMB4 | P28070 | 4/20 | 0.41 |
| ▸ | PSMB6 | P28072 | 4/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.41 |
| ▸ | PSMB10 | P40306 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473601 | 0.90 | PSMB11 (0.44) | ITGB1ITGA4ITGB7MAPK1YAP1 | |
| SCHEMBL23230085 | 0.90 | MAPK1 (0.45) | ITGB1ITGA4ITGB7MAPK1UBE2N | |
| SCHEMBL20815350 | 0.90 | MAPK1 (0.45) | ITGB1ITGA4ITGB7MAPK1UBE2N | |
| SCHEMBL598356 | 0.90 | MAPK1 (0.45) | ITGB1ITGA4ITGB7MAPK1UBE2N | |
| SCHEMBL6840497 | 0.90 | MAPK1 (0.45) | ITGB1ITGA4ITGB7MAPK1UBE2N | |
| SCHEMBL29371746 | 0.90 | MAPK1 (0.45) | ITGB1ITGA4ITGB7MAPK1UBE2N | |
| SCHEMBL6480786 | 0.89 | MAPK1 (0.44) | ITGB1ITGA4ITGB7MAPK1UBE2N | |
| SCHEMBL22023402 | 0.89 | MAPK1 (0.44) | ITGB1ITGA4ITGB7MAPK1UBE2N | |
| SCHEMBL3744009 | 0.89 | MAPK1 (0.44) | ITGB1ITGA4ITGB7MAPK1UBE2N | |
| SCHEMBL4648918 | 0.89 | MAPK1 (0.44) | ITGB1ITGA4ITGB7MAPK1UBE2N |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | claimed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | claimed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | claimed |
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |