Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948678 | 0.80 | ADORA2A (0.41) | F2HDAC6KMT2AALDH1A1MAPK1 | |
| SCHEMBL6948592 | 0.70 | FDPS (0.55) | HDAC6MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL10423399 | 0.70 | MEN1 (0.56) | MEN1KMT2ANPC1TP53KDM4E | |
| SCHEMBL1038315 | 0.69 | KDM4E (0.69) | SMN1; SMN2NPC1KDM4ELMNA | |
| SCHEMBL30052297 | 0.69 | HDAC6 (0.54) | HDAC6ALDH1A1EGFRPTGS2KDM4E | |
| SCHEMBL452417 | 0.69 | HDAC6 (0.54) | HDAC6ALDH1A1EGFRPTGS2KDM4E | |
| SCHEMBL1950890 | 0.67 | CYP11B1 (0.57) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14736671 | 0.67 | HDAC1 (0.53) | HDAC6ALDH1A1MAPTLMNA | |
| SCHEMBL3118173 | 0.66 | SMN1; SMN2 (0.69) | MEN1KMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL28184787 | 0.66 | FGFR1 (0.45) | HDAC6ALDH1A1PTGS2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962921-B2 | Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2005-11-08 | — | — | US | disclosed |