Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647601 | 0.91 | C5AR1 (0.36) | CRHR1C5AR1TSHR | |
| SCHEMBL651024 | 0.90 | C5AR1 (0.47) | CRHR1C5AR1TSHRACHE | |
| SCHEMBL650398 | 0.89 | CRHR1 (0.48) | CRHR1C5AR1TSHR | |
| SCHEMBL1915460 | 0.88 | CRHR1 (0.42) | CRHR1C5AR1TSHR | |
| SCHEMBL650117 | 0.88 | C5AR1 (0.42) | CRHR1C5AR1TSHRACHE | |
| SCHEMBL1915566 | 0.86 | C5AR1 (0.45) | CRHR1C5AR1TSHRACHE | |
| SCHEMBL1915352 | 0.86 | C5AR1 (0.42) | C5AR1TSHR | |
| SCHEMBL648908 | 0.85 | CRHR1 (0.40) | CRHR1C5AR1TSHR | |
| SCHEMBL14572836 | 0.85 | CRHR1 (0.49) | CRHR1C5AR1TSHR | |
| SCHEMBL650018 | 0.84 | C5AR1 (0.46) | CRHR1C5AR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |