Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 7/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.87 |
| ▸ | NPC1 | O15118 | 1/20 | 0.87 |
| ▸ | RAB9A | P51151 | 1/20 | 0.87 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.83 |
| ▸ | GAA | P10253 | 2/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.73 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | CCR1 | P32246 | 2/20 | 0.62 |
| ▸ | CCR2 | P41597 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13662472 | 0.92 | MAPT (0.84) | KDM4EMAPTRXFP1ALDH1A1NPC1 | |
| SCHEMBL6781571 | 0.81 | RXFP1 (1.00) | KDM4EMAPTRXFP1ALDH1A1ATM | |
| SCHEMBL12540328 | 0.77 | KDM4E (1.00) | KDM4EMAPTRXFP1ALDH1A1NPC1 | |
| SCHEMBL6778710 | 0.77 | CCR1 (1.00) | KDM4EMAPTRXFP1ALDH1A1ATM | |
| SCHEMBL14563954 | 0.76 | RXFP1 (0.87) | KDM4EMAPTRXFP1ALDH1A1NPC1 | |
| SCHEMBL1943153 | 0.75 | RXFP1 (0.76) | KDM4EMAPTRXFP1ALDH1A1NPC1 | |
| SCHEMBL8776183 | 0.72 | MAPT (0.57) | KDM4EMAPTRXFP1ALDH1A1NPC1 | |
| SCHEMBL6720980 | 0.71 | MEN1 (0.70) | KDM4EMAPTRXFP1ALDH1A1NPSR1 | |
| SCHEMBL5597999 | 0.71 | RXFP1 (0.58) | KDM4EMAPTRXFP1ALDH1A1NPC1 | |
| SCHEMBL8776238 | 0.70 | MAPT (0.54) | KDM4EMAPTRXFP1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936633-B2 | Pyrrolidinone derivatives | UCB S.A. (BE) | 2005-08-30 | — | — | US | claimed |
| US-20040157914-A1 | Pyrrolidinone derivatives | UCB, S.A. | 2004-08-12 | — | — | US | claimed |
| US-6727275-B2 | ANTIINFLAMMATORY, ANTIALLERGEN, AND ANTIASTHMATIC AGENTS | UCB, S.A./N.V. (BE) | 2004-04-27 | — | — | US | claimed |
| EP-2089383-B1 | 3-HYDR0XY-1,5-DIHYDR0-PYRR0L-2-ONE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE FOR THE TREATMENT OF ULCER, CANCER AND OTHER DISEASES | PROBIODRUG AG (DE) | 2015-09-16 | — | — | EP | disclosed |
| WO-2008055945-A1 | 3-HYDR0XY-1,5-DIHYDR0-PYRR0L-2-ONE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE FOR THE TREATMENT OF ULCER, CANCER AND OTHER DISEASES | PROBIODRUG AG (DE) | 2008-05-15 | — | — | WO | disclosed |
| US-6936633-B2 | Pyrrolidinone derivatives | UCB S.A. (BE) | 2005-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157914-A1 | Pyrrolidinone derivatives | CCR2, CCR1, CCL2 | KDM4E 2561/4885MAPT 2829/4885RXFP1 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.