Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.63 |
| ▸ | PPARA | Q07869 | 1/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 14/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 14/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 14/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 14/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 14/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 14/20 | 0.62 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.61 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2360407 | 0.92 | HDAC3 (0.59) | PPARGPPARAHDAC3HDAC4HDAC1 | |
| SCHEMBL5881122 | 0.86 | PPARG (0.59) | PPARGPPARAHDAC3HDAC4HDAC1 | |
| SCHEMBL13329870 | 0.78 | NPC1 (0.66) | PPARGPPARAHDAC3HDAC4HDAC1 | |
| SCHEMBL20982671 | 0.77 | CHEK2 (0.56) | PPARGPPARAHDAC3HDAC4HDAC1 | |
| SCHEMBL14539300 | 0.76 | HDAC1 (0.74) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6475372 | 0.76 | PDE3B (0.57) | PPARGHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL21017805 | 0.75 | CHEK2 (0.67) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13305860 | 0.75 | PPARG (0.64) | PPARGPPARAHDAC3HDAC4HDAC1 | |
| SCHEMBL20445328 | 0.75 | NPC1 (1.00) | KDM4ENPC1ALDH1A1TP53HPGD | |
| SCHEMBL7049254 | 0.75 | HDAC1 (0.72) | PPARGPPARAHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855714-B2 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-02-15 | — | — | US | disclosed |
| EP-1404321-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | Schering Aktiengesellschaft (DE) | 2004-04-07 | — | — | EP | disclosed |
| US-20030055057-A1 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutial agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AG (DE) | 2003-03-20 | — | — | US | disclosed |
| WO-2003004023-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055057-A1 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutial agents as well as pharmaceutical preparations that contain these derivatives | ARG2, MSR1, ARG1 | PPARG 41/4885PPARA 108/4885HDAC3 198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.