Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.69 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.67 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.50 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.47 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6486526 | 0.91 | HDAC1 (0.64) | PLA2G2APLA2G4BPLA2G4AHDAC1MCL1 | |
| SCHEMBL11718046 | 0.87 | HRH3 (0.56) | PLA2G2APLA2G4BPLA2G4AHDAC1ALDH1A1 | |
| SCHEMBL5020600 | 0.86 | HDAC1 (0.71) | PLA2G2APLA2G4BPLA2G4AHDAC1MCL1 | |
| SCHEMBL1832304 | 0.84 | HAO1 (0.54) | PLA2G2APLA2G4BPLA2G4AHDAC1ALDH1A1 | |
| SCHEMBL11728353 | 0.83 | PLA2G2A (0.61) | PLA2G2APLA2G4BPLA2G4AHDAC1ALDH1A1 | |
| SCHEMBL6477384 | 0.83 | APEX1 (0.58) | PLA2G2APLA2G4BPLA2G4AHDAC1MCL1 | |
| SCHEMBL28104567 | 0.83 | PLA2G2A (0.51) | PLA2G2APLA2G4BPLA2G4AHDAC1ALDH1A1 | |
| SCHEMBL1932895 | 0.82 | CYP1A2 (0.62) | PLA2G2AHDAC1ALDH1A1RAB9AMEN1 | |
| SCHEMBL26085771 | 0.81 | HDAC1 (0.64) | PLA2G2APLA2G4BPLA2G4AHDAC1MCL1 | |
| SCHEMBL1982703 | 0.80 | HDAC8 (0.67) | PLA2G4BHDAC1ALDH1A1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887863-B2 | Hydrazide and alkoxyamide angiogenesis inhibitors | ABBOTT LABORATORIES (US) | 2005-05-03 | — | — | US | disclosed |
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | disclosed |
| US-20040167126-A1 | Hydrazide and alkoxyamide angiogenesis inhibitors | ABBVIE INC. | 2004-08-26 | — | — | US | disclosed |
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | disclosed |
| US-20020002152-A1 | Hydrazide and alkoxyamide angiogenesis inhibitors | ABBOTT LABORATORIES | 2002-01-03 | — | — | US | disclosed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167126-A1 | Hydrazide and alkoxyamide angiogenesis inhibitors | METAP2, METAP1, ANPEP | PLA2G2A 1442/4885PLA2G4B 1779/4885PLA2G4A 2181/4885 |
| US-20020002152-A1 | Hydrazide and alkoxyamide angiogenesis inhibitors | METAP2, METAP1, ANPEP | PLA2G2A 1442/4885PLA2G4B 1779/4885PLA2G4A 2181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.