Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.78 |
| ▸ | HTR7 | P34969 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6473994 | 0.99 | HTR1A (0.77) | HTR1AHTR7DRD2ADRA1DADRA1A | |
| SCHEMBL6486972 | 0.92 | HTR1A (0.79) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL6482862 | 0.91 | HTR1A (0.77) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL6484692 | 0.84 | HTR1A (0.81) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL6971387 | 0.83 | HTR1A (0.79) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL13282715 | 0.81 | HTR1A (0.73) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL1578260 | 0.81 | HTR1A (1.00) | HTR1ADRD2 | |
| SCHEMBL6482449 | 0.80 | HTR1A (0.65) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL10021790 | 0.79 | HTR1A (0.88) | HTR1AADRA1DADRA1AADRA1BMAPT | |
| SCHEMBL10021791 | 0.79 | HTR1A (0.88) | HTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894052-B1 | Serotonergic receptor antagonist | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2005-05-17 | — | — | US | claimed |
| EP-1000046-B1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI CHEM PHARM (CH) | 2003-11-26 | — | — | EP | claimed |
| JP-2001512111-A | — | — | 2001-08-21 | — | — | JP | claimed |
| EP-1000046-A1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 2000-05-17 | — | — | EP | claimed |
| WO-1999006383-A1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-02-11 | — | — | WO | claimed |